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ISSN : 1225-0171(Print)
ISSN : 2287-545X(Online)
Korean Journal of Applied Entomology Vol.50 No.3 pp.227-233
DOI :

비단벌레[Crysochroa fulgidissima] 에탄올추출물의 No 증강 및 염증인자억제활성

초록

NO and Cytokine Production due to Crysochroa fulgidissima

안미영, 김순자, 정혜경, 서윤정, 박해철, 이영보, 김미애

Abstract

 ,  , Crysochroa fulgidissima (Bidan-beole, Spanish fly) is traditionally used as a crude drug and insecticide in the East Asia and Korea, respectively. This study investigated the effect of ethanol extract of C. fulgidissima on the NO production activity. The C fulgidissima extract was a potent inducer of NO production in CP AE cells and a stimulator of endothelial nitric oxide synthase in a dose-dependent manner. This study also evaluated the anti-inflammatory activity of this extract by determining the level ofICAM-l, VCAM-l, and prostaglandin E2 from HUVEC cells. Although C. fulgidissima extract was a potent inducer of NO production in the CP AE cells, it showed weak inhibitory effects on vascular endothelial growth factor (VEGF) production in HUVEC cells. HPLC and GC-MS analysis of the ethanol extract of C. fulgidissima revealed the presence of cantharidin.
Crysochroa fulgidissima larvae extract, NO production, cantharidin, 비단벌레, 산화질소생성, 염증인자억제

Reference

Vol. 40 No. 4 (2022.12)

Journal Abbreviation Korean J. Appl. Entomol.
Frequency Quarterly
Doi Prefix 10.5656/KSAE
Year of Launching 1962
Publisher Korean Society of Applied Entomology
Indexed/Tracked/Covered By