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ISSN : 1225-0171(Print)
ISSN : 2287-545X(Online)
Korean Journal of Applied Entomology Vol.46 No.2 pp.229-234
DOI :

호박벌 일벌독의 성분 분석 및 생리활성 탐색

초록

Protein Composition and Biological Activities of Bombus ignifus Venom

한상미, 이광길, 여주홍, 권해용, 우순옥, 윤형주, 김미애, 김원태, 백하주

Abstract

  Pure Bombus ignitus venom samples were submitted to two-dimensional gel electrophoresis. A total of 64 excised spots were analyzed by mass spectrometry. Three main proteins resulted in the identification have not been described in other bee venoms before. Dose-dependence against human carcinoma (Hep3B, BT-20, A549 and AGS) were observed from 1 ng/㎖ to 100 ng/㎖. Expecially, the treatment of 100 ng/㎖ B. ignitus venoms showed the highest cytotoxicity with 55% against hepatocellular carcinoma (Hep3B). The B. ignitus venoms showed strong antimicrobial activities against Enterococcus faecium and Shigella sonnei, and practically antimicrobial activity against the other microorganisms tested. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of E. faecium and S. sonnei, were 0.256 ug/㎖, respectively.
Bombus ignitus, Bee venom, Biological activity, Antibacterial, Anticancer, 호박벌, 벌독, 생리활성, 항균, 항암

Reference

Vol. 40 No. 4 (2022.12)

Journal Abbreviation Korean J. Appl. Entomol.
Frequency Quarterly
Doi Prefix 10.5656/KSAE
Year of Launching 1962
Publisher Korean Society of Applied Entomology
Indexed/Tracked/Covered By